Presenting LUCC Researchers: Cancer and its Environment – Remodelling the Tumour Niche

Presenting LUCC Researchers: Cancer and its Environment – Remodelling the Tumour Niche

CHRIS D MADSEN is Associated Senior Lecturer at the Department of Laboratory Medicine, Division of Translational Cancer Research, Lund University and a member of the Lund University Cancer Center (LUCC)                                      

WHAT IS THE FOCUS OF YOUR RESEARCH?

Our work focusses on the synergistic relationship between cancer cells and their surroundings, e.g. stromal fibroblasts and the extracellular matrix. My group works on matrix remodelling in cancer progression and metastasis. Our work is focused on mapping the 3D topology of the tumour niches. To achieve this, we use animal models and highly sophisticated imaging.

WHAT IMPACT DO YOU HOPE THAT YOUR RESEARCH WILL HAVE ON CANCER CARE/CANCER PATIENTS?

The spread of metastasis is responsible for the majority of cancer-related mortality. Our main goal is to identify new ways to stop the metastatic cascade and to identify ways of killing of already existing metastases. Another goal of our research is to improve drug delivery -and efficacy, by interfering and rewiring the tumour microenvironment.

WHAT ARE THE POSSIBILITIES FOR COMMERCIALIZING YOUR RESEARCH?

We are working on a novel mechanism that regulates mechano-transduction and YAP/TAZ signalling, and our aim is to develop drugs that can fine-tune this balance. The development of such drugs have widespread clinical potential in both cancer, fibrosis and regenerative medicine.

WHERE CAN I READ MORE ABOUT YOUR RESEARCH?

https://portal.research.lu.se/portal/en/persons/chris-madsen(53192ae1-4bc5-4f83-b80b-6fa8655518b3).html

 

Lunds universitet - Institutionen för immunteknologi