Presenting LUCC Researchers: Deciphering Radiation Resistance in Brain Tumors

Presenting LUCC Researchers: Deciphering Radiation Resistance in Brain Tumors

ALEXANDER PIETRAS, PhD, is Associate Senior Lecturer at the Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University and a member of the Lund University Cancer Center.

WHAT IS THE FOCUS OF YOUR RESEARCH?

My lab is interested in mechanisms underlying therapeutic resistance in glioblastoma multiforme (GBM) – the highest-grade glioma and deadliest brain tumor. Despite aggressive treatment with surgery, irradiation, and sometimes chemotherapy, tumors invariably recur as incurable lesions.

WHAT IMPACT DO YOU HOPE THAT YOUR RESEARCH WILL HAVE ON CANCER CARE/CANCER PATIENTS?

Tumor cells with stem cell characteristics are thought to be responsible for therapeutic resistance in brain tumors. Despite the crucial role of radiation resistance in patient mortality, few viable therapeutic strategies have been identified to target these resistant cells. Using mouse models of glioma and primary human glioma cells, we aim to characterize differences between tumor cells within the same tumor, specifically with regards to radiation resistant stem-like tumor characteristics, including the molecular signaling pathways underlying therapeutic resistance, and microenvironmental control over tumor cell behavior. The overall goal of the lab is developing novel therapeutic strategies sensitizing resistant cells in malignant brain tumors to conventional therapeutics.

WHERE CAN I READ MORE ABOUT YOU AND YOUR RESEARCH? http://www.med.lu.se/labmedlund/translational_cancer_research/research_g...

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