LUCC@MV Researcher Portrait: Beyond Malignant Cells – Investigating Tumor Architecture

LUCC@MV Researcher Portrait: Beyond Malignant Cells – Investigating Tumor Architecture

KRISTIAN PIETRAS is Professor at the Department of Laboratory Medicine, Division of Translational Cancer Research, Lund University and a member of LUCC@MV.

WHAT IS THE FOCUS OF YOUR RESEARCH?

We consider a tumor as a miniature organ in its own right, comprising multiple cell types that collectively evolve into a clinically manifested disease. Our overarching aim is to functionally define the cellular elements of a tumor based on their utility as therapeutic targets and clinical biomarkers through an integrated set of basic, pre-clinical and translational studies.

WHAT IMPACT DO YOU HOPE THAT YOUR RESEARCH WILL HAVE ON CANCER CARE/CANCER PATIENTS?

The stromal compartment comprises a hitherto underexploited source for factors harboring prognostic, predictive or therapeutic potential. Our vision is that a pre-treatment biopsy from each cancer patient will be screened, either transcriptionally or histologically, for the content of signatures derived from different subsets of stromal and malignant cells. The analysis of the composition of constituent cellular subsets and the tumor architecture, will enable informed decisions on the course of therapy. 

WHAT ARE THE POSSIBILITIES FOR COMMERCIALIZING YOUR RESEARCH?

Our integrated approach combining high resolution studies of basic biology with the use of disease-specific genetically engineered models of cancer with proven translational capacity and analysis of well-defined clinical materials holds the promise of contributing to the development of new therapeutic strategies.

WHERE CAN I READ MORE ABOUT YOU AND YOUR RESEARCH

https://portal.research.lu.se/portal/sv/organisations-researchgroups/experimental-oncology(0d197123-7954-4a80-8fcf-131c31b67b69).html

Twitter @KPietraslab

Lunds universitet - Institutionen för immunteknologi