Beyond the Lab: Building Smarter Chemistry Strategies for Discovery

Small discovery teams face a paradox: breakthrough science doesn’t move forward without reliable chemistry, but building in-house chemistry capabilities is expensive, time-consuming, and often unnecessary at an early stage. This interactive half-day event addresses real challenges lean discovery teams face, and hands real-world solutions to make the next steps.

Three Takeaways

• Collaboration across the value chain drives innovation.
• There is tension between scale and precision, as ‘more’ should also mean useful and meaningful.
• Tomorrow’s science starts with today’s solutions, scalability and sustainability.

Speakers

• Anna Maria Eisele, Sr. Scientist, AstraZeneca
• Filip Paulsen, Associate Principal Scientist, RG Discovery
• Slavko Rast, Sr. Principal Scientist, Amgen
• Christian Loeffeld, Head of Business Operations, Alipheron
• Paula Nichols, Sr. Scientist & Co-founder, Synple Chem

Agenda

12:30-13:15 Welcome, registration, lunch and mingle

13:15-13:20 Opening / Introduction

Erik Steinfelder, eMolecules

13:20-13:50 Kick-off presentation: Thinking Inside the Box – for Sustainable Compound Distribution

Anna Maria Eisele, AstraZeneca

13:50-14:20 Case Study: Hit-finding in CDK9 – a selective scaffold from virtual screening

Filip Paulsen, Associate Principal Scientist, RG Discovery

14:20-14:35 Short break

14:35-15:05 Case Study: DELete KRAS G12C: Covalent DNA-Encoded Library Screening Empowered the Discovery of a Structurally Novel, Potent, and CNS-penetrant KRAS G12C Inhibitor

Slavko Rast, Amgen

15:05-15:35 Searching ultra-large make-on-demand spaces for active scaffolds in 2D and 3D

Christian Loeffeld, Alipheron

15:35-16:00 Interactive discussion with Q&A: From virtual libraries to real-world hits

Panelists: Anna Maria Eisele, AstraZeneca; Filip Paulsen, RG Discovery; Slavko Rast, Amgen; and Christian Loeffeld, Alipheron.

Moderator: Paula Nichols, Synple Chem AG

16:00 Closing and mingling

About eMolecules

eMolecules about itself: eMolecules is the leading online platform to buy specialty chemistry and hard-to-find molecules, accessible in just a few clicks. Real-time pricing, availability, and shipping information, and integrated with major eProcurement and eCommerce platforms. One platform, one order, one aggregated shipping. The mission behind that simplicity is to make chemical compound sourcing simpler, so scientists can spend more time on the work that gets medicines to the people who need them.