Scientist/Senior Scientist In vitro Immuno-Oncology
About Asgard Therapeutics
Asgard Therapeutics is a privately held biotech company pioneering in vivo direct cell reprogramming for cancer immunotherapy, backed by Johnson & Johnson Innovation – JJDC, Inc., RV Invest, Novo Holdings, Boehringer Ingelheim Venture Fund, and Industrifonden. Our lead candidate, AT-108, is a first-in-class gene therapy that reprograms tumor cells into antigen-presenting dendritic cells (cDC1), triggering a personalized and potent anti-tumor immune response.
Position Overview
The ideal in vitro scientist candidate will have a background in immuno-oncology and hands-on experience in in vitro research. The role will involve executing in vitro experiments, analyzing data, troubleshooting technical issues, and contributing to ongoing projects. Strong interpersonal, verbal, and written communication skills are required. Experimental rigor, scientific curiosity, and the ability to work in a fast-paced environment, adapting to evolving priorities, are musts.
Key responsibilities
- Conduct in vitro experiments using cell lines and primary samples, including monolayer cultures, spheroids, organoids, and tumoroids, to assess reprogramming efficiency.
- Establish and optimize new models and methods to characterize immune responses, and troubleshoot technical issues.
- Perform immunological assays including flow cytometry, ELISpot, T-cell co-culture assays, and cytokine profiling.
- Analyze and summarize data in reports and communicate findings to Asgard's R&D and executive leadership team.
- Assist in experiment planning, execution, and documentation according to standard protocols.
Qualifications
- PhD degree in Immunology, Cancer Biology, Biomedicine, or a related life science discipline.
- Extensive experience with general in vitro 2D and 3D cell culture techniques, including handling and processing primary tissue samples.
- Basic understanding of cancer immunotherapies is critical, knowledge of dendritic cell and T cell biology is a plus.
- Experience in tumor biology-related in vitro assays, including multi-color flow cytometry for ELISpot and T-cell cytotoxicity assays.
- Experience with small molecule and viral vectors handling is a plus.
- Felasa B or equivalent animal handling certification and in vivo experience is a plus.
- Strong organizational skills and ability to work in a team-oriented environment.
- Good written and verbal communication skills in English.
Literature
- Ascic E, at al. In vivo dendritic cell reprogramming for cancer immunotherapy. Science 386, eadn9083 (2024). DOI:10.1126/science.adn9083
- Zimmermannova O, et al. Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science Immunology 8, eadd4817 (2023). DOI: 10.1126/sciimmunol.add4817
Application
Please email your CV, cover letter and contact information for two references to careers@asgardthx.com to apply. Asgard will review applications on a rolling basis and only shortlisted candidates will be contacted.